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KMID : 1189120120090020078
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대한의학유전학회지
2012 Volume.9 No. 2 p.78 ~ p.83
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Maternal Plasma Hepatocyte Growth Factor Concentrations in Women Who Subsequently Developed Preeclampsia
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Kim Shin-Young
Park So-Yeon
Kim Mi-Jin
Ryu Hyun-Mee
Kim Moon-Young
Choi Kyu-Hong
Kwak Dong-Wook
Han Yoo-Jung
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Abstract
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Purpose: The aim of this nested case-control study was to investigate the association between hepatocyte growth factor (HGF) concentrations in maternal plasma and the risk of developing preeclampsia.
Materials and Methods: Plasma HGF concentration were measured in 52 women who subsequently developed preeclampsia and 104 normal pregnant women at the time of genetic amniocentesis (15-20 weeks) by enzyme-linked immunosorbent assay.
Results: Maternal plasma HGF concentrations were significantly higher in women with subsequent preeclampsia (median: 737.8 ng/mL vs. 670.4 ng/mL, P=0.003) than in normal controls. However, HGF concentrations were not significantly different between subgroups by preeclamptic complications. After adjusting for potential confounding factors, women with HGF concentrations ≥702.5 ng/mL had a 3.2-fold increased risk (95% CI 2.7-5.4, P<0.001) of subsequent development of preeclampsia compared with women with HGF concentrations <702.5 ng/mL.
Conclusion: Elevated maternal plasma HGF concentrations in the early second-trimester are associated with an increased risk of developing preeclampsia.
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KEYWORD
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Plasma, Hepatocyte growth factor, Risk factor, Subsequent preeclampsia
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